There isn’t a lot of reliable scientific information about the therapeutic effects of CBD, despite the widespread beliefs and anecdotal evidence of its advantages. It is impossible to determine the reality because the findings of so many of the CBD research currently conducted are contradictory.

One group of researchers proposed a number of explanations for the inconsistencies in the available CBD research, including changes in the body’s metabolism and interactions with CBD. They first sought to know if different CBD preparations would affect how the body absorbs CBD. They also investigated how body composition affected the absorption of CBD. The group also investigated the notion that CBD affects heart rate variability. What they discovered might alter how CBD research is carried out in the future.

Effect of Planning

Five distinct CBD preparations with varying levels of solubility, CBD concentrations, and extra formulation ingredients were examined by the research team. Each of them had 30 mg of CBD and were all taken orally. They evaluated the pharmacokinetics of CBD by charting the blood levels of the subjects over a 4-hour period to see how the preparation altered the body’s reaction to CBD.

The preparation with 5 percent CBD in liquid form had the highest maximum concentration and reached its maximum concentration the fastest. The maximum concentration of CBD powder dissolved in water took the longest to attain and had the lowest maximum concentration of all the tested preparations. While the CBD tincture’s absorption rate was a little faster and its overall concentration was higher, the outcomes were comparable to those of CBD powder. It would appear that tinctures often produce an absorption with a delayed release. There may be a specific concentration of CBD that is better for absorption because, interestingly, the 20 percent CBD concentration in liquid functioned similarly to the 5 percent one but did not achieve the same maximum concentration.

Body composition effects

The data gathered from all of the preparations showed considerable variances. Body composition was the cause of those variances. Only a few of the trends the team noticed held up to statistical examination. Lean body mass was associated with a shorter time for CBD concentration to reach its peak when it was present in a liquid formulation of 5 percent CBD. Higher body mass index was linked to a longer time for the tincture to reach peak concentration. Other characteristics, such as age being positively linked with a greater overall concentration with the administration of 5 percent CBD in liquid form, were statistically significant for specific preparations.

The findings demonstrate that the body itself plays a significant role in CBD absorption in addition to the impact that various CBD preparations have on how the body processes them.

Heart rate variability is affected

Heart rate variability may aid in the prediction of cardiac events and serve as a sign of general heart health. Few studies have examined the impact of CBD on heart rate variability, and as far as the researchers are aware, none have examined the immediate effects of CBD alone.

The team discovered that CBD only has a moderate effect on heart rate variability after examining a number of heart rate variability metrics, and they regarded the difference induced by CBD to be physiologically irrelevant.

According to the results of this study, the body’s own mechanisms affect how CBD interacts with and is processed by it. Although CBD has a lot of potential, further research is necessary to fully understand how various CBD formulations affect the body.


[1] Williams NNB et al. Comparing the Pharmacokinetics, Body Composition, and Heart Rate Variability of Five Oral Cannabidiol Preparations in Adult Humans. 2021. Pharmaceuticals; 14(1): 35. Posted on January 6, 2021; doi:10.3390/ph14010035 [5 is the journal impact factor .68] [Ten times quoted]

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